ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice
Hair cells of the inner ear, the mechanosensory receptors, convert sound waves into neural signals that are passed to the brain via the auditory nerve. Little is known about the molecular mechanisms that govern the development of hair cell-neuronal connections. We ascertained a family with autosomal recessive deafness associated with a common cavity inner ear […]
Comparison of various bone cement ossiculoplasty techniques and functional results
Objective: In this study, functional results of different bone cement ossiculoplasty techniques are compared. Methods: Retrospective case review at a tertiary referral center. Patients who underwent middle ear surgery and bone cement ossiculoplasty between 2006-2012 were included. A total of 52 patients, including 30 patients with ‘Incus to stapes’ (Group 1) and 13 patients with […]
Cochlear Implantation in Neurobrucellosis
Background: Neurobrucellosis is a disease consisting of a wide spectrum of complications such as peripheral neuropathy, cranial nerve involvement, ataxia, meningeal irritation, paraplegia, seizures, coma, and even death. The vestibulocochlear nerve seems to be the most commonly affected cranial nerve (10%). We present a patient with neurobrucellosis whose auditory perception and speech intelligibility skill performances […]
Prognostic Factors in Sudden Sensorineural Hearing Loss
Background: Sudden sensorineural hearing loss (SSNHL) is still a complex and challenging process which requires clinical evidence regarding its etiology, treatment and prognostic factors. Therefore, determination of prognostic factors might aid in the selection of proper treatment modality. Aims: The aim of this study is to analyze whether there is correlation between SSNHL outcomes and […]
Histopathology of inner ear malformations: Do we have enough evidence to explain pathophysiology?
Objective: To investigate the histopathology of inner ear malformations (IEMs) in order to explain their pathophysiology. Method: Light microscopy was used to study 33 specimens exhibiting various IEMs in the collection of the Otopathology Laboratory at Harvard University’s Massachusetts Eye and Ear Infirmary. Results: The investigation found 18 incidences of cochlear hypoplasia (CH) (3 CH-I, […]
Recent Rehabilitation Experience with Pediatric ABI Users
Objective: The aim of this study is to describe the rehabilitative outcomes of pediatric auditory brainstem implant (ABI) users in the Department of Otolaryngology in the Hacettepe University. It was a retrospective study, and all patients’ files were reviewed. Materials and methods: The data was collected from 41 children who were fitted with ABI between […]
Manubrio-stapedioplasty: New surgical technique for malleus and incus fixation due to tympanosclerosis
This paper reports the authors’ technique of manubrio-stapedioplasty using glass ionomer cement for malleus and incus fixation due to tympanosclerosis. A retrospective case review was conducted of five patients with conductive hearing loss (mean pre-operative air-bone gap of 42.75 dB) treated in a tertiary referral centre. The hearing results of a manubrio-stapedial bone cement ossiculoplasty […]
Novel domain-specific POU3F4 mutations are associated with X-linked deafness: Examples from different populations
Mutations in the POU3F4 gene cause X-linked deafness type 3 (DFN3), which is characterized by inner ear anomalies. Three Turkish, one Ecuadorian, and one Nigerian families were included based on either inner ear anomalies detected in probands or X-linked family histories. Exome sequencing and/or Sanger sequencing were performed in order to identify the causative DNA […]
A new cochlear implant electrode with a “cork”-type stopper for inner ear malformations
Objective Gusher in inner ear malformations is common in patients with incomplete partition type I and type III. It is also common in less severe form as oozing in incomplete partition type II and large vestibular aqueduct. It is important to prevent cerebrospinal fluid (CSF) escape around the electrode to prevent meningitis. Methods The custom-made […]
CSF gusher in cochlear implantation: The risk of missing CT evidence of a cochlear base defect in the presence of otherwise normal cochlear anatomy
Intraoperative cerebrospinal fluid (CSF) leakages from the cochleostomy site – known as gushers – are a serious complication of cochlear implantation surgery in cases of congenital deafness. They occur as the result of abnormal communication between CSF in the internal auditory canal and perilymph in the cochlea. Gushers are well recognized as occurring in a […]
Oval window atresia: A novel surgical approach and pathognomonic radiological finding
The facial nerve usually occupies the oval window area in patients with oval window atresia. During exploration, if the facial nerve is discovered to lie in the oval window area, this is usually regarded as a contraindication for further surgical intervention. The aim of the present paper is to demonstrate the preoperative pathognomonic radiological sign […]
Incidence of otitis media with effusion and long-term clinical findings in children with cleft lip and palate types
This study aims to investigate the incidence of otitis media with effusion and to report long-term clinical findings in children with cleft lip and palate types. Between March 2000 – October 2010, medical data of 175 patients (84 females, 95 males; mean age 8 years; range, 4 to 20 years) who were operated due to […]
Radiological quiz. Sudden sensorineural hearing loss due to multiple sclerosis
Objective: A case with sudden sensorineural hearing loss (SSNHL) owing to multiple sclerosis (MS) who had clinical and dramatic radiological improvement just after medical therapy was reported in this article. Method: Case report and review of related literature. Results: A 22-year-old female patient with MS related SSNHL was presented in this article. Magnetic resonance imaging […]
Radiological quiz. Sudden sensorineural hearing loss due to multiple sclerosis
Objective: A case with sudden sensorineural hearing loss (SSNHL) owing to multiple sclerosis (MS) who had clinical and dramatic radiological improvement just after medical therapy was reported in this article. Method: Case report and review of related literature. Results: A 22-year-old female patient with MS related SSNHL was presented in this article. Magnetic resonance imaging […]
Auditory Brainstem Implantation in Children
Until last decade, use of auditory brainstem implant (ABI) was restricted to adults and children with severe inner ear malformations and cochlear nerve aplasia did not have any option for hearing rehabilitation. Use of ABI opened a new era for this group of patients. In this review article, definite and probable indications of ABI for […]
Stapes Cerrahisi Sonrası İç Kulağın Erken Bilgisayarlı Tomografi Bulguları ve Klinik Korelasyonları
Amaç: Temporal kemik travmasından ve stapes luxation’dan kaynaklanan pnömolabrin, sensorinöral işitme kaybı (SNHL) ile ilişkilendirilmiştir. Bu çalışmanın temel amacı, iyatrojenik perilifatik fistülün oluşturulduğu stapedotomi sonrası pnömolabyrinth insidansını ve hacmini belirlemek ve bunu işitme kaybı ve vertigo ile ilişkilendirmektir. Çalışma tasarımı: Prospektif çalışma. Ayar: Tersiyer başvuru merkezi. Hastalar ve yöntemler: Elli stapedotomi hastası otoskleroz nedeniyle ameliyat edildi ve 50, 20’sine […]
Early Computed Tomography Findings of the Inner Ear After Stapes Surgery and Its Clinical Correlations
Objective: Pneumolabyrinth resulting from temporal bone trauma and stapes luxation has been associated with sensorineural hearing loss (SNHL). The principal purpose of this study was to determine the incidence and volume of pneumolabyrinth after stapedotomy in which iatrogenic perilymphatic fistula is created and to also correlate this with possible hearing loss and vertigo. Study design: […]
Results of Audiological Evaluation in Patients with Idiopathic Intracranial Hypertension
Background: Idiopathic intracranial hypertension (IIH) is a syndrome characterized by increased intracranial pressure (ICP) without focal signs for neurological dysfunction except for occasional fifth, sixth, and seventh cranial nerve palsies. Presenting symptoms most commonly are headache and visual loss. These patients may also present with complaints about neuro-otological symptoms like hearing loss, and tinnitus. In […]